病原：Rickettsiales-like prokaryote

宿主：Haliotis midae

主要症状：发病初期，没有明显的症状，发病持续一段时间后足部肌肉发白、出现水泡后出现溃烂表面有大小不一的溃烂孔。

RLP inclusion bodies (arrows) within infected digestive gland tissue of H. midae. Haematoxylin and eosin. Scale bar, 20 μm.

In situ hybridization of infected H. midae digestive gland with the species-specific probe combination P108, PRIK16SF and PRIK16SR. Arrows indicate RLP inclusion bodies showing positive signals. Scale bar, 20 μm.

In situ hybridization of infected H. midae digestive gland with the universal eubacterial probe EUB338 (positive control). Arrows indicate inclusion bodies showing positive signals. Scale bar, 100 μm.

In situ hybridization of infected H. midae digestive gland sample with the E. coli probe PEC109 (negative control). Arrows indicate inclusion bodies. Scale bar, 20 μm.

In situ hybridization of T. sarmaticus sample with the species-specific probe combination P108, PRIK16SF and PRIK16SR. Arrows indicate inclusion bodies. Scale bar, 20 μm.

(参考文献：Rael Horwitz et al.,2016)