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杩戞棩锛屼腑鍥芥按浜х瀛︾爺绌堕櫌鍗楁捣姘翠骇鐮旂┒鎵�涓崕椴庝繚鎶ょ爺绌跺洟闃熷湪鐜閲嶉噾灞炴睘姹℃煋鐗╁涓崕椴庡辜浣撶殑姣掓�ф満鍒剁爺绌跺彇寰楁柊杩涘睍锛屼负寮�灞曟繏鍗辩墿绉嶄腑鍗庨矌鐨勬捣娲嬬幆澧冮闄╄瘎浼版彁渚涗簡绉戝渚濇嵁銆傜浉鍏崇爺绌舵垚鏋滀互鈥?span style="font-family: "times new roman";">Integrated transcriptomics and metabolomics reveal the toxic mechanisms of mercury exposure to an endangered species Tachypleus tridentatus鈥濅负棰樺彂琛ㄤ簬Environmental Toxicology and Pharmacology鏈熷垔锛圛F 4.3锛変笂锛堣阿鏈ㄥ▏鍜岄矋铏炲洯涓哄叡鍚岀涓�浣滆�咃紝棰夋檽鍕囧崥澹负閫氳浣滆�咃級銆?/p>
姹炴槸涓�绉嶄互澶氱褰㈠紡銆佸箍娉涜�屾寔涔呭湴姹℃煋姘翠綋鐨勯噸閲戝睘锛屽叿鏈夐珮姣掓�с�侀潪鐢熺墿闄嶈В鎬у拰鐢熺墿瀵岄泦鎬э紝琚仈鍚堝浗鐜瑙勫垝缃插垪涓哄鍏ㄧ悆鑼冨洿浜х敓褰卞搷鐨勫寲瀛︾墿璐紝宸叉垚涓哄叏鐞冨箍娉涘叧娉ㄧ殑鐜姹℃煋鐗╀箣涓�銆?/p>
鍗楁捣鎵�鍥㈤槦搴旂敤杞綍缁勫鍜屼唬璋㈢粍瀛︾浉缁撳悎鐨勬妧鏈紝鐮旂┒鎻ず浜嗘睘鏆撮湶瀵逛腑鍗庨矌骞间綋鐨勭幆澧冩瘨鐞嗗拰鑽悊瀛︿綔鐢ㄦ満鍒躲�傜粨鏋滃彂鐜帮細锛?锛夋睘鏆撮湶寮曡捣骞奸矌浣撳唴缁嗚優姣掓�э紝鏈轰綋閫氳繃涓婅皟澶氭硾绱燗鍜岀粍缁囪泲鐧介叾B鍩哄洜琛ㄨ揪浠ヤ績杩涜泲鐧借川闄嶈В锛涳紙2锛夋睘鏆撮湶寮曡捣骞奸矌蹇冭绠＄郴缁熸瘨鎬э紝鐩稿叧鏍囧織鐗╁彂鐢熸樉钁楀彉鍖栵紝鍖呮嫭蹇冩埧閽犲翱鑲斤紙ANP锛夈�佽绠＄揣寮犵礌杞崲閰讹紙ACE锛夊拰绁炵粡鑲紽MRFamide鍙椾綋锛涳紙3锛夋睘鏆撮湶瑙﹀彂鑴傝川浠ｈ阿绱婁贡锛屽鑷寸値鎬ц剛璐ㄦ憾琛�纾疯剛閰拌儐纰憋紙lysoPC锛夈�佺櫧涓夌儻D4鍜屽墠鍒楄吅绱燛2寮傚父澧炲姞锛涳紙4锛夌粏鑳炶壊绱燩450s閫氳矾鐨勯噸瑕佸熀鍥犺婵�娲伙紝浜х敓鎶楃値鐗╄川閲嶅缓浣撳唴绋虫�侊紝涓鸿瘎浼版睘姣掓�ф彁渚涗簡鏁忔劅鐨勬寚鏍囷紱锛?锛夋睘鏆撮湶寮曡捣绮炬皑閰哥敓鎴愬彈闃伙紝鍙兘閫氳繃鐮村潖mTOR淇″彿閫氳矾鑰屽奖鍝嶅辜椴庣敓闀垮彂鑲诧紱锛?锛変唬璋㈢墿S-鑵鸿嫹鐢茬～姘ㄩ吀鍜岀簿鑳哄鍔狅紝鎻愮ず鑳炲唴鐢插熀渚涗綋澶辫 锛屽彲鑳戒笌姹炵殑鐢插熀鍖栨湁鍏炽�?/p>
姝ゅ墠锛屽崡娴锋墍鍥㈤槦鍙戣〃浜庛�婄敓鎬佹瘨鐞嗗鎶ャ�嬬殑鈥淗g2+ 瀵逛腑鍥介矌骞间綋鎬ユ�ф瘨鎬у強MT 鐨勮瀵兼晥搴斺�濓紙2020锛?5( 6) : 300-307锛夎鏂囧凡琛ㄦ槑锛孒g2+瀵归矌骞间綋鐨勬瘨鎬х被鍨嬩负鎬ユ�р叀锛屽叾24h銆?8h銆?2h鍜?6h鐨凩C50鍒嗗埆涓?5.013銆?.084銆?.008鍜?.683 mg鈥-1锛屽畨鍏ㄨ川閲忔祿搴︿负0.473 mg鈥-1銆傚伐涓氭椂浠ｇ幆澧冧腑姹炴薄鏌撶殑澧炲姞鍙兘浼氳繘涓�姝ュ嵄鍙婅鐗╃銆傜粨鍚堟娆＄爺绌剁粨鏋滐紝杩涗竴姝ユ繁鍏ユ彮绀烘睘褰卞搷椴庡辜浣撲唬璋㈢ǔ鎬佺殑姣掔悊鍜岃嵂鐞嗗浣滅敤鏈哄埗锛屾湭鏉ュ湪涓崕椴庣殑鍏蜂綋淇濇姢鎺柦鏂归潰涓嶅簲蹇借娴锋磱鐜姹℃煋銆?/p>
璁烘枃閾炬帴锛?/p>
https://www.sciencedirect.com/science/article/pii/S1382668923002879
锛堝樊寮傝〃杈惧熀鍥?/span>DEGs鍒嗗竷鍜?/span>KEGG閫氳矾娉ㄩ噴锛?/span>
锛堜笌鑴傝川浠ｈ阿鐩稿叧鐨勫樊寮備唬璋骇鐗╃儹鍥撅級
寰俊鎵竴鎵?br>鍒嗕韩鍒版湅鍙嬪湀
杩戞棩锛屼腑鍥芥按浜х瀛︾爺绌堕櫌鍗楁捣姘翠骇鐮旂┒鎵�涓崕椴庝繚鎶ょ爺绌跺洟闃熷湪鐜閲嶉噾灞炴睘姹℃煋鐗╁涓崕椴庡辜浣撶殑姣掓�ф満鍒剁爺绌跺彇寰楁柊杩涘睍锛屼负寮�灞曟繏鍗辩墿绉嶄腑鍗庨矌鐨勬捣娲嬬幆澧冮闄╄瘎浼版彁渚涗簡绉戝渚濇嵁銆傜浉鍏崇爺绌舵垚鏋滀互鈥?span style="font-family: "times new roman";">Integrated transcriptomics and metabolomics reveal the toxic mechanisms of mercury exposure to an endangered species Tachypleus tridentatus鈥濅负棰樺彂琛ㄤ簬Environmental Toxicology and Pharmacology鏈熷垔锛圛F 4.3锛変笂锛堣阿鏈ㄥ▏鍜岄矋铏炲洯涓哄叡鍚岀涓�浣滆�咃紝棰夋檽鍕囧崥澹负閫氳浣滆�咃級銆?/p>
姹炴槸涓�绉嶄互澶氱褰㈠紡銆佸箍娉涜�屾寔涔呭湴姹℃煋姘翠綋鐨勯噸閲戝睘锛屽叿鏈夐珮姣掓�с�侀潪鐢熺墿闄嶈В鎬у拰鐢熺墿瀵岄泦鎬э紝琚仈鍚堝浗鐜瑙勫垝缃插垪涓哄鍏ㄧ悆鑼冨洿浜х敓褰卞搷鐨勫寲瀛︾墿璐紝宸叉垚涓哄叏鐞冨箍娉涘叧娉ㄧ殑鐜姹℃煋鐗╀箣涓�銆?/p>
鍗楁捣鎵�鍥㈤槦搴旂敤杞綍缁勫鍜屼唬璋㈢粍瀛︾浉缁撳悎鐨勬妧鏈紝鐮旂┒鎻ず浜嗘睘鏆撮湶瀵逛腑鍗庨矌骞间綋鐨勭幆澧冩瘨鐞嗗拰鑽悊瀛︿綔鐢ㄦ満鍒躲�傜粨鏋滃彂鐜帮細锛?锛夋睘鏆撮湶寮曡捣骞奸矌浣撳唴缁嗚優姣掓�э紝鏈轰綋閫氳繃涓婅皟澶氭硾绱燗鍜岀粍缁囪泲鐧介叾B鍩哄洜琛ㄨ揪浠ヤ績杩涜泲鐧借川闄嶈В锛涳紙2锛夋睘鏆撮湶寮曡捣骞奸矌蹇冭绠＄郴缁熸瘨鎬э紝鐩稿叧鏍囧織鐗╁彂鐢熸樉钁楀彉鍖栵紝鍖呮嫭蹇冩埧閽犲翱鑲斤紙ANP锛夈�佽绠＄揣寮犵礌杞崲閰讹紙ACE锛夊拰绁炵粡鑲紽MRFamide鍙椾綋锛涳紙3锛夋睘鏆撮湶瑙﹀彂鑴傝川浠ｈ阿绱婁贡锛屽鑷寸値鎬ц剛璐ㄦ憾琛�纾疯剛閰拌儐纰憋紙lysoPC锛夈�佺櫧涓夌儻D4鍜屽墠鍒楄吅绱燛2寮傚父澧炲姞锛涳紙4锛夌粏鑳炶壊绱燩450s閫氳矾鐨勯噸瑕佸熀鍥犺婵�娲伙紝浜х敓鎶楃値鐗╄川閲嶅缓浣撳唴绋虫�侊紝涓鸿瘎浼版睘姣掓�ф彁渚涗簡鏁忔劅鐨勬寚鏍囷紱锛?锛夋睘鏆撮湶寮曡捣绮炬皑閰哥敓鎴愬彈闃伙紝鍙兘閫氳繃鐮村潖mTOR淇″彿閫氳矾鑰屽奖鍝嶅辜椴庣敓闀垮彂鑲诧紱锛?锛変唬璋㈢墿S-鑵鸿嫹鐢茬～姘ㄩ吀鍜岀簿鑳哄鍔狅紝鎻愮ず鑳炲唴鐢插熀渚涗綋澶辫 锛屽彲鑳戒笌姹炵殑鐢插熀鍖栨湁鍏炽�?/p>
姝ゅ墠锛屽崡娴锋墍鍥㈤槦鍙戣〃浜庛�婄敓鎬佹瘨鐞嗗鎶ャ�嬬殑鈥淗g2+ 瀵逛腑鍥介矌骞间綋鎬ユ�ф瘨鎬у強MT 鐨勮瀵兼晥搴斺�濓紙2020锛?5( 6) : 300-307锛夎鏂囧凡琛ㄦ槑锛孒g2+瀵归矌骞间綋鐨勬瘨鎬х被鍨嬩负鎬ユ�р叀锛屽叾24h銆?8h銆?2h鍜?6h鐨凩C50鍒嗗埆涓?5.013銆?.084銆?.008鍜?.683 mg鈥-1锛屽畨鍏ㄨ川閲忔祿搴︿负0.473 mg鈥-1銆傚伐涓氭椂浠ｇ幆澧冧腑姹炴薄鏌撶殑澧炲姞鍙兘浼氳繘涓�姝ュ嵄鍙婅鐗╃銆傜粨鍚堟娆＄爺绌剁粨鏋滐紝杩涗竴姝ユ繁鍏ユ彮绀烘睘褰卞搷椴庡辜浣撲唬璋㈢ǔ鎬佺殑姣掔悊鍜岃嵂鐞嗗浣滅敤鏈哄埗锛屾湭鏉ュ湪涓崕椴庣殑鍏蜂綋淇濇姢鎺柦鏂归潰涓嶅簲蹇借娴锋磱鐜姹℃煋銆?/p>
璁烘枃閾炬帴锛?/p>
https://www.sciencedirect.com/science/article/pii/S1382668923002879
锛堝樊寮傝〃杈惧熀鍥?/span>DEGs鍒嗗竷鍜?/span>KEGG閫氳矾娉ㄩ噴锛?/span>
锛堜笌鑴傝川浠ｈ阿鐩稿叧鐨勫樊寮備唬璋骇鐗╃儹鍥撅級
绮ゅ叕缃戝畨澶?4010502001742鍙?/a>